Comprehensive hereditary cancer panel

What it measures

Breast and ovarian cancer genes (BRCA1, BRCA2, PALB2 and others)Lynch syndrome genes (MLH1, MSH2, MSH6, PMS2, EPCAM)Colorectal, gastric and pancreatic cancer genesEndocrine, kidney and skin cancer genes30 or more genes in total

This is a screening test, not a diagnosis. Results are explained by a doctor and, where needed, a genetic counsellor. High-probability results are confirmed with diagnostic testing arranged with your doctor.

Where it is tested. Genomic tests are performed by an accredited specialist genomics laboratory, in Australia or overseas. We name the laboratory, its accreditation and where it is on this page before ordering opens, and you consent to that before you order. The laboratory receives your sample and a KnowLuna sample number, never your name or contact details, and destroys the sample and raw sequencing data after reporting.

Who it's for

Women with cancer on both sides of the family, several cancer types in relatives, cancers diagnosed young, or who want one test covering the main inherited cancer syndromes. Adults aged 18 and over.

What you'll learn, and what you won't

A multi-gene panel looks for changes across the genes behind the common hereditary cancer syndromes at once. It finds more than a single-syndrome test, and it also returns more variants of uncertain significance, which is why the result is always explained by a genetic counsellor. A positive result leads to a personal screening plan and to cascade testing for relatives, usually rebated.

A genetic test is one input to a doctor's assessment, not a diagnosis on its own. If anything needs prompt attention a doctor contacts you directly.

How it works

Order online. Either use the request your own doctor has signed, or a KnowLuna women's health doctor reviews your details and requests the test.
Give your sample; collection details are confirmed at launch. Saliva kit at home or a blood draw. Any time. Once in a lifetime.
Results are ready about 3 to 4 weeks from the sample reaching the laboratory, explained in your account, with a doctor to talk them through and a genetic counsellor where a result calls for it.

How you collect

Sample collection details are confirmed at launch. Whichever option applies to this test, it is the same accredited test and the same report.

Join the waitlist to hear the moment collection details are announced for your area.

Common questions

How is this different from the breast and ovarian panel?

It includes those genes and adds the genes behind bowel and uterine cancer (Lynch syndrome), stomach, pancreatic, kidney, skin and endocrine cancers. Choose it where the family history is broader than breast and ovarian cancer, or where you want one test covering the main syndromes.

What is a variant of uncertain significance?

A gene change that has not yet been classified as harmful or harmless. Most are later reclassified as harmless. It is not treated as a positive result, and a genetic counsellor explains it to you.